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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PSEN1
All Species:
12.42
Human Site:
T327
Identified Species:
21.03
UniProt:
P49768
Number Species:
13
Phosphosite Substitution
Charge Score:
0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49768
NP_000012.1
467
52668
T327
T
E
R
E
S
Q
D
T
V
A
E
N
D
D
G
Chimpanzee
Pan troglodytes
XP_001149972
443
50485
S313
Q
R
R
V
S
K
N
S
K
Y
N
A
E
S
R
Rhesus Macaque
Macaca mulatta
XP_001088524
384
43068
S254
E
N
D
D
G
G
F
S
E
E
W
E
A
Q
R
Dog
Lupus familis
XP_547503
717
78133
S564
I
F
P
A
L
I
Y
S
S
A
M
V
W
T
V
Cat
Felis silvestris
Mouse
Mus musculus
P49769
467
52621
S327
A
E
R
E
T
Q
D
S
G
S
G
N
D
D
G
Rat
Rattus norvegicus
P97887
468
52771
T328
E
R
E
E
T
Q
D
T
G
T
G
S
D
D
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514754
455
50711
Q325
Q
E
E
E
E
E
P
Q
S
E
N
R
R
N
R
Chicken
Gallus gallus
Q4JIM4
468
52812
E328
P
A
N
Q
S
Q
N
E
D
A
E
A
D
D
G
Frog
Xenopus laevis
O12976
433
48282
D303
S
D
D
N
G
G
F
D
T
T
W
E
D
H
R
Zebra Danio
Brachydanio rerio
Q9W6T7
456
50963
D320
P
T
A
Q
A
E
D
D
G
G
F
T
P
A
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O02194
541
59286
Q348
T
T
T
T
R
A
T
Q
N
S
L
A
S
P
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P52166
444
50016
V314
V
K
R
I
P
Q
K
V
Q
I
E
S
N
T
T
Sea Urchin
Strong. purpuratus
XP_001178715
518
58077
S368
G
Q
E
D
Q
T
V
S
S
D
Q
E
V
N
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O64668
453
49290
T320
E
H
S
T
S
V
G
T
R
G
N
M
E
D
R
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
89.7
82.2
46.2
N.A.
92.7
92.5
N.A.
62.3
82.2
77.3
70.8
N.A.
47.6
N.A.
49
55.6
Protein Similarity:
100
90.7
82.2
52
N.A.
96.5
96.5
N.A.
73.6
89.7
83
79
N.A.
63.4
N.A.
64
68.1
P-Site Identity:
100
13.3
0
6.6
N.A.
60
46.6
N.A.
13.3
46.6
6.6
6.6
N.A.
6.6
N.A.
20
6.6
P-Site Similarity:
100
40
13.3
13.3
N.A.
80
60
N.A.
26.6
60
20
26.6
N.A.
13.3
N.A.
40
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.3
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
8
8
8
8
0
0
0
22
0
22
8
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
15
15
0
0
29
15
8
8
0
0
36
36
0
% D
% Glu:
22
22
22
29
8
15
0
8
8
15
22
22
15
0
8
% E
% Phe:
0
8
0
0
0
0
15
0
0
0
8
0
0
0
0
% F
% Gly:
8
0
0
0
15
15
8
0
22
15
15
0
0
0
36
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
8
0
0
8
0
8
0
0
0
8
0
0
0
0
0
% I
% Lys:
0
8
0
0
0
8
8
0
8
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
8
0
0
0
0
0
8
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
8
8
0
0
0
% M
% Asn:
0
8
8
8
0
0
15
0
8
0
22
15
8
15
0
% N
% Pro:
15
0
8
0
8
0
8
0
0
0
0
0
8
8
0
% P
% Gln:
15
8
0
15
8
36
0
15
8
0
8
0
0
8
0
% Q
% Arg:
0
15
29
0
8
0
0
0
8
0
0
8
8
0
36
% R
% Ser:
8
0
8
0
29
0
0
36
22
15
0
15
8
8
0
% S
% Thr:
15
15
8
15
15
8
8
22
8
15
0
8
0
15
8
% T
% Val:
8
0
0
8
0
8
8
8
8
0
0
8
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
15
0
8
0
8
% W
% Tyr:
0
0
0
0
0
0
8
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _